At affinity, we are positioned to meet the evolving needs of medicinal chemists for exploring structural diversity and novel IP spaces. We focus on building blocks that are Structurally Intriguing, Metabolically Stable, and Convenient to Diversity.
Our chemists are willing to take the synthetic challenges to make unique and hard to find building blocks. We are proud to be the first to make several classes of compounds commercially available for research community. New building blocks are synthesized in our Delaware lab and added to our catalog every month.
We are capable of scaling up most of the building blocks we have. About 5% of our building blocks have been scaled up to multi-kilos or larger quantities. Click here for examples of building blocks we scaled up recently.
If there are building blocks that you are interested, but nowhere to find, please send us an email to info@affinitychem.com, with the structures. We will keep all your compound information confidential.
Pleas click here for detailed building block product list.
Affinity offers you a full spectrum of precisely defined Polyethylene Glycol (P-PEG) cross-linkers for all of your biological applications. Our P-PEG linkers generally bear two orthogonal reactive groups that will covalently attach with certain functional groups such as amines and sulfhydryls. Our P-PEG linkers are single molecular weight compounds with fixed length. These products provide the diverse methods for peptide, protein, or other macromolecular conjugation and immobilization. Click here to view our line of products.
By collaborating with Professor Joe Fox at University of Delaware, we are able to commercialize a new class of bioorthogonal labeling reagents, based on Tetrazine-Trans-cyclooctene (TCO) ligation. This uniquely rapid labeling technique has becoming a very powerful tool for in vivo labeling and imaging. Click here for details.
We offer a variety of ligands and precious metal catalysts at very competitive price. Our products are manufactured according to vigorous industry standards. Each batch of products is assayed and fully characterized to assure quality.
With our extensive knowledge and experience in catalysis technologies, we can provide our customers the services they need:
Catalyst screening at Laboratory Scale
Custom catalysts or precursors manufacturing
Process optimization and scale up
High temperature, high pressure hydrogenation and hydrogenolysis at various
scale (from gram to metric ton)
Recovery of values from spent catalyst residues
Unnatural amino acids (UAAs) are non-proteinogenic amino acids that either occur naturally or chemically synthesized. Their intrinsic structural diversity and functional versatility make them ideal as chiral building blocks and molecular scaffolds. They represent a powerful tool in drug discovery and lead optimization when incorporated into therapeutic peptidomimetics and peptide analogs.
We offer a broad range of UAAs (we are the sole supplier to over 100 products) to facilitate your research program. Click here for the list of UUAs we offered.
At Affinity, we want to provide you the most unique peptide synthesis service. All our peptides are purified, lyophilized peptide with minimum purity of 95%. We specialize in the following synthesis service:
Incorporation of Unnatural Amino Acids
Stable Isotope Labeling
PEGylation, Phosphorylation, Lipid Conjugation
Cylcic Peptide Synthesis
We have a team of Ph.D. chemists dedicated to standard and reference compounds synthesis. We mainly focus on the synthesis of compounds that are not commercially available through other vendors or new compounds.
Synthesis of high purity reference standards (>99% pure or higher) used in
pharmacopoeia assays and tests.
Synthesis of reference APIs for clients' biological effect comparison.
Synthesis of metabolites based on proposed structures to facilitate structural
identification and profiling of metabolites by pharmaceutical companies.
Synthesis stable isotope labeled (2H, 13C, 15N) APIs, impurities, metabolites or
other reference compounds.
Synthesis of batch samples, and impurities to assist product registration by
agrochemical companies.
Our expertise in heterocyclic chemistry, organometallic chemistry, and cross-coupling reactions make us capable to synthesize optical-electronic sensitive materials.
Our hole transport materials are based on triarylamines, with ultra-high purity. The HTMs have been used successfully in organic photoreceptor devices, solar cells, OLEDs and other organic electronics applications. In solar cells, HTMs can enable efficiencies in excess of 20%. Some recent research even showed that triacrylamines can play an important part in making highly stable perovskite solar cells by preventing metal atoms from the electrode from diffusing into the perovskite.
Our charge generation materials include benzimidazole perylene (BZP), hydroxygallium phthalocyanine, titanyl phthalocyanine, These Charge Generation materials are for use in electrophotography, OLED, and organic solar cells.
